Cisco AnyConnect Secure Mobility Client “Failed to initialize connection subsystem”

Quit the Cisco AnyConnect Window.

Right click – C:\Program Files (x86)\Cisco\Cisco AnyConnect Secure Mobility Client\vpnui.exe

Click on the “Run compatibility troubleshooter” button

Choose “Try recommended settings”.

The wizard suggests Windows 8 compatibility.

Click “Test Program”.  This will open the program.

Close